Further galphimines from a new population of Galphimia glauca

Abstract

Both DNA barcoding and phylogenetic data of the studied botanical material suggested the existence a newpopulation ofGalphimia glauca. Their leaves afforded three newnor-3,4-seco-friedelanes named galphimines M-O, together with known galphimines D, E, G, and I. Galphimines M and N possess bicyclic orthoacetates whichare thefirst examples of orthoesters found in the Malpighiaceae family, while galphimine O has a 27,20-δ-lactone moiety. The structures elucidation followed from spectroscopic means and the absolute configurationfollowed from single crystal X-ray diffraction analyses. Tests for antibacterial and antifungal activities of gal-phimines N and M showed no promising effects